ISSN No:2250-3676 ----- Crossref DOI Prefix: 10.64771
Scholarly Peer Reviewed and Fully Referred Open Access Multidisciplinary Monthly Research Journal
FORMULATION AND DEVELOPMENT OF STATISTICAL OPTIMIZATION OF GASTRO-RETENTIVE DRUG DELIVERY SYSTEM: IN-VIVO AND IN-VITRO STUDYID: 1657 Abstract :This Study Focuses On The Formulation And Optimization Of A Gastro-retentive Drug Delivery System (GRDDS) For Lansoprazole And Clarithromycin, Used In The Treatment Of Helicobacter Pylori-associated Peptic Ulcers. The Aim Is To Enhance Gastric Residence Time And Improve The Local Therapeutic Effect Through Floating Tablets. A Design Of Experiment (DoE) Approach, Specifically Box-Behnken Design (BBD) Or Central Composite Design (CCD), Is Used For Statistical Optimization. In-vitro Buoyancy, Drug Release, And In-vivo Gastric Retention Are Evaluated To Confirm The Efficacy Of The Formulation. Key Word- Peptic Ulcer And Role Of H. Pylori, Prolonged Gastric Retention, Macrolide Antibiotic |
Published:25-9-2025 Issue:Vol. 25 No. 9 (2025) Page Nos:396-402 Section:Articles License:This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. How to CiteMrs. Ghule Ujjwala Vilas,Dr. Kazi Mehraj Abukalam,Dr. Govind S Asane, FORMULATION AND DEVELOPMENT OF STATISTICAL OPTIMIZATION OF GASTRO-RETENTIVE DRUG DELIVERY SYSTEM: IN-VIVO AND IN-VITRO STUDY , 2025, International Journal of Engineering Sciences and Advanced Technology, 25(9), Page 396-402, ISSN No: 2250-3676. |