Abstract :

Lumbar Degenerative Disease Frequently Necessitates Surgical Intervention, With Intraoperative And Postoperative Blood Loss Posing A Significant Challenge. Tranexamic Acid (TXA), An Antifibrinolytic Agent, Has Proven Efficacy In Reducing Blood Loss; However, The Optimal Route Of Administration In Spine Surgery Remains Uncertain. Objective: To Evaluate And Compare The Effectiveness Of Intravenous Versus Topical TXA In Reducing Postoperative Blood Loss Among Patients Undergoing Lumbar Spine Fusion Surgery. Materials And Method: The Present Prospective Observational Study Enrolled 40 Patients Undergoing Lumbar Spinal Fusion. Participants Were Allocated Into Two Groups: Group A Received Intravenous TXA (15 Mg/kg Diluted In 100 ML Saline, Administered 15 Minutes Before Incision Closure), While Group B Received Topical TXA (2 G Soaked In A Gelatin Sponge, Applied Intraoperatively). Outcomes Assessed Included Postoperative Drain Output, Perioperative Hemoglobin Changes, And Hospital Stay Duration. Statistical Analysis Was Performed Using Appropriate Tests, With P < 0.05 Considered Significant. Results: Baseline Demographic Characteristics Were Comparable, Except For A Significantly Higher BMI In The Intravenous Group (p = 0.022). The Topical Group Had A Higher Mean Drain Output (173.75 ± 58.41 ML) Compared To The Intravenous Group (141 ± 48.33 ML), Though This Difference Did Not Reach Statistical Significance (p = 0.060). Both Groups Experienced A Postoperative Hemoglobin Drop, But The Difference Was Not Statistically Significant (p = 0.760). The Duration Of Hospital Stay Was Longer In The Topical Group (8.95 ± 3.28 Days) Compared To The Intravenous Group (7.4 ± 3.21 Days), Without Statistical Significance (p = 0.139). Conclusion: Intravenous And Topical TXA Demonstrated Comparable Efficacy And Safety In Reducing Postoperative Blood Loss Following Lumbar Spine Fusion. Intravenous TXA Showed A Trend Toward Lower Drain Output, While Topical TXA Remains A Viable Alternative,

Published:

25-9-2025

Issue:

Vol. 25 No. 9 (2025)

Page Nos:

194-204

Section:

Articles

License:

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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